Recently, LC/MS/MS has been introduced in many laboratories as an alternative technology for TDM (besides Immunoassays). Alsachim developed a reagent kit based on LC/MS/MS analytical method for the quantification of the immunosuppressant drug in plasma: Mycophenolic acid (MPA) and its glucuronide (MPA-G).
The DOSIMYCO™ kit is an in vitro diagnostic device for the rapid and multiplex assay of the immunosuppressant drug for LC/MS, thanks to in-house production of stable isotope-labeled internal standards with deuterium and carbon-13. This ready-to-use kit is also for routine LC/MS/MS analysis of this immunosuppressant in plasma sample.
DOSIMYCO™ is available for 200 analysis RUO 227-40300-58 (Europe) / 227-40300-91 (Japan)
Method of analysis: LC/MS/MS
Parameter: Mycophenolic acid and its glucuronide MPA-G
Analysis time: 1.5 min
Limit of quantification:
- MPA : < 0.1 mg/L
- MPA-G : < 1 mg/L
Linearity:
- MPA : up to 100 mg/L
- MPA-G : up to 500 mg/L
Specimen: in plasma
Storage: Samples can be stored for up to 7 days at +4°C +/-2°C. For longer storage, it is recommended to freeze the sample at -20°C +/-5°C after collection.
Sample preparation:
- Transfer calibrator or control or human blood sample into a microtube
- Add reconstituted Internal standards pool
- Add extraction buffer
- Shake and centrifuge
- Extract the supernatant
- Insert in LC/MS/MS and analyze
Injection volume: 0.1–50 µL
Ionisation: ESI positive
MS/MS-Mode: MRM
Comment: DOSIMYCO™ reagent kit is delivered with all documentation required to use properly the product (complete instructions Manual, safety data sheets, quality an analysis certificates, etc.)
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