Anticoagulants are commonly used to manipulate the blood coagulation process by inhibiting thrombus formation. Anticoagulants include Vitamin K antagonist, Thrombin inhibitor and Factor X inhibitor. Due to the pharmacological mode of action, the use of anticoagulants may be associated with an increased risk of potential or over bleeding from any tissue or organ which may result in post hemorrhagic anemia.
A measurement of anticoagulants in plasma is essential to verify drug adherence and dose selection.
Thanks to Mass spectrometry’s specificity and sensitivity, MRM Technology and the use of in-house stable labeled internal standards, Alsachim developed DOSINACO™ kit enabling the simultaneous quantification of 9 anticoagulants in plasma. (Acenocoumarol, Apixaban, Argatroban, Betrixaban, Dabigatran, Edoxaban, Fluindione, Rivaroxaban and Warfarin)
DOSINACO™ is available for 200 analysis RUO 227-40500-58 (Europe) / 227-40500-91 (Japan)
DOSINACO is a registered trademark of Alsachim, a Shimadzu Group Company. This page may contain references to products that are not available in your country. This product could be available for research use only depending of your country. Please contact us to check the availability of these products in your country.
Method of analysis: LC-MS/MS
Parameter: Acenocoumarol, Apixaban, Argatroban, Betrixaban, Dabigatran, Edoxaban, Fluindione, Rivaroxaban and Warfarin.
Analysis time: 7 min
Specimen: in plasma
Storage: Samples can be stored for up to 7 days at +4°C +/-2°C. For longer storage, it is recommended to freeze the sample at -20°C +/-5°C after collection.
| Limit of Quantitation | Linearity |
Acenocoumarol | < 100 µg/L | up to 10,000 µg/L |
Apixaban | < 10 µg/L | up to 1,000 µg/L |
Argatroban | < 10 µg/L | up to 1,000 µg/L |
Betrixaban | < 10 µg/L | up to 1,000 µg/L |
Dabigatran | < 10 µg/L | up to 500 µg/L |
Edoxaban | < 10 µg/L | up to 1,000 µg/L |
Fluindione | < 100 µg/L | up to 10,000 µg/L |
Rivaroxaban | < 10 µg/L | up to 1,000 µg/L |
Warfarin | < 100 µg/L | up to 10,000 µg/L |
Sample preparation:
- Transfer calibrator or control or human blood sample into a microtube
- Add reconstituted Internal standards pool
- Add extraction buffer
- Shake and centrifuge
- Extract the supernatant
- Insert in LC-MS/MS and analyze
Injection volume: 0.1–50 µL
Ionisation: ESI positive
MS/MS-Mode: MRM
Comment: DOSINACO™ reagent kit is delivered with all documentation required to use properly the product (complete instructions Manual, safety data sheets, quality an analysis certificates, etc.)
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